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Zhang:

 

TGF-beta1

verhoogd

in ME/CVS.

 

 

 

 


 

Up-regulation of TGF-β1 mRNA expression in peripheral blood mononuclear cells of patients with chronic fatigue syndrome.

J Formos Med Assoc. 2011 Nov;110(11):701-4. doi:10.1016/j.jfma.2011.09.006.

Zhang HY, Liu ZD, Hu CJ, Wang DX, Zhang YB, Li YZ.

 

 

BACKGROUND/PURPOSE:

 

It has been shown that the abnormality

in immune cells in chronic fatigue syndrome (CFS) patients

is closely associated with the participation of TGF-β.

 

In order to study the relationship between TGF-β1 and CFS,

we investigated the mRNA levels of TGF-β1

in peripheral blood mononuclear cells (PBMCs) in patients with CFS.

 

 

METHODS:

 

Fluorescent quantitative real time reverse-transcription

polymerase chain reaction (FQ-RT-PCR) was performed to test

TGF-β1 mRNA expression in PBMCs

in 63 cases of CFS, 50 cases of disease controls, and 50 cases of healthy controls.

 

 

RESULTS:

 

The mean value of TGF-β1 mRNA expression in CFS patients was ΔΔCt=1.170.58,

which was significantly higher than

the disease controls (ΔΔCt=0.071.08, df=111, p < 0.01) and

the healthy controls (ΔΔCt=0.001.63, df=111, p < 0.01).

 

No significant difference was detected

between disease and healthy controls (p > 0.05).

 

 

CONCLUSION:

 

The expression of TGF-β1 in PBMCs

is significantly elevated in patients with CFS.

 

It might be correlated to the pathogenesis of the disease.

 

 

 

PMID: 22118314

 

 

http://www.sciencedirect.com/science/article/pii/S0929664611000702

http://www.ncbi.nlm.nih.gov/pubmed/22118314

http://www.jfma-online.com/article/S0929-6646(11)00070-2/abstract