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Bansal:

afwijkende

hoeveelheden van

B-cel-ondersoorten

suggereren

ontregelde

humorale immuunresponse.

 

 

 

 


 

Volgens een studie van Bansal en collega's duiden afwijkingen in de hoeveelheden

van diverse B-cel-ondersoorten wellicht op een rol voor auto-immuniteit in ME/CVS.

 

Bradley, Ford en Bansal observeerden

  • relatief hogere concentraties naïeve B-cellen
  • (B-cellen die die nog niet blootgesteld zijn aan/geactiveerd zijn door de antigeen),

  • lagere aantallen transitionele B-cellen
  • (B-cellen die recent het beenmerg hebben verlaten) en

  • lagere concentraties plasmablasten (de voorlopers van plasma B-cellen,
  • gevormd bij blootstelling aan de antigeen, bijv. virus of "lichaamseigen" antigeen).

 

 

 

bron:

Cherie L. Green, John Ferbas and Barbara A. Sullivan (2012).

B Cells in Health and Disease – Leveraging Flow Cytometry to Evaluate Disease Phenotype and the Impact of Treatment with Immunomodulatory Therapeutics,

Clinical Flow Cytometry – Emerging Applications, M.Sc. Ingrid Schmid (Ed.),

ISBN: 978-953-51-0575-6, InTech, DOI: 10.5772/38288.

http://www.intechopen.com/books/clinical-flow-cytometry-

emerging-applications/b-cells-in-health-and-disease-leveraging-

flow-cytometry-to-evaluate-disease-phenotype-and-the-impact

 

 

 


 

 

 

Altered functional B cell subset populations

in patients with ME/CFS compared to healthy controls

Clin Exp Immunol. 2013 Apr;172(1):73-80. doi: 10.1111/cei.12043.

Bradley AS, Ford B, Bansal AS.

 

 

Abstract

 

Chronic fatigue syndrome (CFS)

is a heterogeneous disorder of unknown aetiology characterized by

disabling fatigue, headaches, sleep disturbance and several other symptoms.

 

The onset of CFS may follow a viral infection or period of stress.

 

Patients with CFS do not have hypogammaglobulinaemia,

predisposition to recurrent bacterial infections or symptoms of autoimmunity.

 

To date, defects in B cell numbers or function

have not been shown in the literature.

 

However,

treatment with anti-B cell therapy using Rituximab

has recently shown benefit to CFS patients.

 

We therefore postulated that

patients with CFS had a subtle humoral immune dysfunction, and

performed extended B cell immunophenotyping.

 

We undertook a detailed characterization of

the proportions of the different B cell subsets

in 33 patients with CFS fulfilling the Canadian and Fukada criteria for CFS and

compared these with 24 age- and gender-matched healthy controls (HC).

 

CFS patients had

greater numbers of naive B cells as a percentage of lymphocytes:

6,3 versus 3,9% in HC (P=0,034),

greater numbers of naive B cells as a percentage of B cells:

65 versus 47% in controls (P=0,003),

greater numbers of transitional B cells:

1,8 versus 0,8% in controls (P=0,025) and

reduced numbers of plasmablasts:

0,5 versus 0,9% in controls (P=0,013).

 

While the cause of these changes is unclear,

we speculate whether they may suggest a subtle tendency to autoimmunity.

 

 

 

http://www.ncbi.nlm.nih.gov/pubmed/23480187