Een recente studie van Brenu en collega's van de Griffith Universiteit toont wederom aan dat
het aantal immunologische afwijkingen in ME/CVS 'overweldigend' is (zie tabel hieronder).
"Ongelovigen" daarentegen spreken liever over "medisch onverklaarblare symptomen" en
stellen dat nadenken over de ziekte ("misinformatie") de symptomen doet 'escaleren' (klik hier)....
Enkele relevante citaten uit de studie:
In T cells, CD73 dampens
the release of pro-inflammatory cytokines
by inhibiting NF-kB activation (77)
promoting a Th2 type response.
...
[T]he NK cells in the CFS/ME patients
are presumably highly activated in response to a potential viral overload
but incapable of eliminating these viruses.
...
In summary,
the findings from this present study confirm
a substantial breakdown in immune tolerance and inflammatory mechanisms
in patients with CFS/ME.
This likely involves
significant impairments in the NK cell function,
over-reactive Tregs, impaired DCs, neutrophils,
dysregulation in cytokine levels and
abnormal production of adenosine.
Collectively these defects are overwhelming and
further confirmatory studies may be required
owing to the multifactorial and heterogeneous nature of the disorder.
The role of adaptive and innate immune cells
in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.
Int Immunol. 2013 Dec 16. doi: 10.1093/intimm/dxt068.
Brenu EW, Huth TK, Hardcastle SL, Fuller K, Kaur M,
Johnston S, Ramos SB, Staines DR, Marshall-Gradisnik SM.
Abstract
Perturbations in immune processes
are a hallmark of a number of autoimmune and inflammatory disorders.
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)
is an inflammatory disorder with possible autoimmune correlates,
characterised by reduced Natural Killer (NK) cell activity,
elevations in regulatory T cells (Tregs) and dysregulation in cytokine levels.
The purpose of this paper is to examine
innate and adaptive immune cell phenotypes and functional characteristics
that have not been previously examined in CFS/ME patients.
30 patients with CFS/ME and 25 non-fatigued controls were recruited for this study.
Whole blood samples were collected from all participants
for the assessment of cell phenotypes, functional properties, receptors,
adhesion molecules, antigens and intracellular proteins using flow cytometric protocols.
The cells investigated included
NK cells, dendritic cells (DCs), neutrophils, B cells, T cells, γδT cells and Tregs.
Significant changes were observed in
in the CFS/ME patients in comparison to the non-fatigued controls.
Alterations in B cells, Tregs, NK cells and neutrophils suggest
significant impairments in immune regulationin CFS/ME and
these may have similarities to a number of autoimmune disorders.
KEYWORDS:
B cells, Degranulation, Dendritic cells, NK cells, γδT cells
PMID: 24343819
http://intimm.oxfordjournals.org/content/early/2013/12/16/intimm.dxt068.abstract
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