Volgens een recente studie van Marshall-Grasdinik en collega's van de Gold Coast Univeristy
gaat ME/CVS gepaard met een scala aan "medisch onverklaarbare" immunologische afwijkingen:
En nu maar hopen dat al die verschillende afweercellen luisteren naar gedragstherapie...
Analysis of the relationship between immune dysfunction and symptom severity
in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)
J Clin Cell Immunol 2014, 5: 190. doi: 10.4172/2155-9899.1000190
Hardcastle SL, Brenu EW, Johnston S, Nguyen T, Huth T, Kaur M,
Ramos S, Salajegheh A, Staines D, Marshall-Gradisnik S.
Abstract
Objective:
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a disabling illness,
characterised by persistent, debilitating fatigue and a multitude of symptoms.
Immunological alterations are prominent in CFS/ME cases,
however little is known about the relationship
between CFS/ME severity and the extent of immunological dysfunction.
The purpose of this study was to assess
innate and adaptive immune cell phenotypes and function of
two groups of CFS/ME patients, bedridden (severe) and mobile (moderate).
Methods:
CFS/ME participants were defined
using the Centres for Disease Prevention and Control (1994 CDC) Criteria for CFS/ME.
Participants were grouped into
healthy controls (n=22, age=40.14 ± 2.38),
moderate/mobile (n=23; age=42.52 ± 2.63) and
severe/bedridden (n=18; age=39.56 ± 1.51) CFS/ME patients.
Flow cytometric protocols were used to examine
neutrophil, monocyte, dendritic cells (DCs), iNKT, Treg,
B, γδ and CD8+ T cell phenotypes,
NK cytotoxic activity and receptors.
Results:
The present data found that
CFS/ME patients demonstrated
significant decreases in
NK cytotoxic activity, transitional and regulatory B cells,
γδ1 T cells, KIR2DL1/DS1, CD94+ and KIR2DL2/L3.
Significant increases in
CD56-CD16+ NKs, CD56dimCD16- and CD56brightCD16-/dim NKs,
DCs, iNKT phenotypes, memory and naive B cells
were also shown in CFS/ME participants.
Severe CFS/ME patients demonstrated
increased CD14-CD16+ DCs, memory and naïve B cells,
total iNKT, iNKT cell and NK phenotypes
compared to moderate CFS/ME patients.
Conclusion:
This study is the first to determine alterations in
NK, iNKT, B, DC and T cell phenotypes
in both moderate and severe CFS/ME patients.
Immunological alterations are present in innate and adaptive immune cells and
sometimes, immune deregulation appears worse in CFS/ME patients with more severe symptoms.
It may be appropriate for CFS/ME patient severity subgroups
to be distinguished in both clinical and research settings
to extricate further immunological pathologies
that may not have been previously reported.
Keywords:
Chronic Fatigue Syndrome, Severity, γδ T cells, Immune,
Natural Killer Cell, iNKT, Cytotoxic Activity, Adaptive
http://www.omicsonline.org/open-access/analysis-of-the-relationship-between-immune-
dysfunction-and-symptom-severity-in-patients-with-chronic-fatigue-2155-9899.1000190.pdf
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