Uit een urineonderzoek van 112 CVS-patiënten door Brewer en collega's bleek dat

93% van de patiënten positief testte voor drie belangrijke mycotoxines

(mycotoxines = gifstoffen of toxines geproduceerd door schimmels):

• aflatoxines (geproduceerd door verschillende species van Fusarium, Myrothecium, Trichoderma, Trichothecium, Cephalosporium, Verticimonosporium en Stachybotrys),
• ochratoxine A (onder meer geproduceerd door Aspergillus ochraceus,

Aspergillus niger, Aspergillus carbonarius en diverse species van Penicillium),

• macrocyclische trichothecenen (o.m. Satratoxin-G en Satratoxin-H , Roridin E

en Verrucarin, afkomstig van Stachybotrys chartarum of Stachybotrys atra).

In hetzelfde onderzoek was/wordt meer dan 90% van de CVS-patiënten blootgesteld

aan gebouwen met waterschade, een belangrijke oorzaak van schimmelvorming.

Detection of mycotoxins in patients with chronic fatigue.

Toxins 2013, 5, 605-617. doi:10.3390/toxins5040605

Brewer JH, Thrasher JD, Straus DC, Madison RA, Hooper D.

Abstract:

Over the past 20 years,

exposure to mycotoxin producing mold

has been recognized as a significant health risk.

Scientific literature has demonstrated

mycotoxins as possible causes of

human disease in water-damaged buildings (WDB).

This study was conducted to determine

if selected mycotoxins could be identified in human urine

from patients suffering from chronic fatigue syndrome (CFS).

Patients (n = 112) with a prior diagnosis of CFS

were evaluated for mold exposure and the presence of mycotoxins in their urine.

Urine was tested for

aflatoxins (AT), ochratoxin A (OTA) and macrocyclic trichothecenes (MT)

using Enzyme Linked Immunosorbent Assays (ELISA).

Urine specimens from 104 of 112 patients (93%)

were positive for at least one mycotoxin (one in the equivocal range).

Almost 30% of the cases had more than one mycotoxin present.

OTA was the most prevalent mycotoxin detected (83%)

with MT as the next most common (44%).

Exposure histories indicated

current and/or past exposure to WDB

in over 90% of cases.

Environmental testing was performed in the WDB

from a subset of these patients.

This testing revealed the presence of

potentially mycotoxin producing mold species and mycotoxins

in the environment of the WDB.

Prior testing in a healthy control population

with no history of exposure to a WDB or moldy environment (n = 55)

by the same laboratory, utilizing the same methods,

revealed no positive cases at the limits of detection.

Keywords:

Mycotoxin; Mold Exposure; Chronic Fatigue Syndrome; Stachybotrys

http://globalindoorhealthnetwork.com/files/

Detection_of_Mycotoxins_in_Patients_with_Chronic_Fatigue_Syndrome_2013.pdf