Veel Gram-positieve bacteriën zijn in staat om uit arginine stikstofoxide te produceren.
En die stikstofoxide vergroot de resistentie van die bacteriën voor antibiotika.
En daarmee komen "kwakzalvers" (die antioxidanten, vitamine C, B12 etc. voorschrijven)
opeens in een ander daglicht te staan...
Antibiotic resistance clue found
Page last updated at 00:35 GMT, Sunday, 13 September 2009 01:35 UK
US scientists have uncovered a defence mechanism in bacteria
that allows them to fend off the threat of antibiotics.
...
http://news.bbc.co.uk/2/hi/health/8248020.stm
Endogenous nitric oxide protects bacteria against a wide spectrum of antibiotics.
Science. 2009 Sep 11;325(5946):1380-4.
Gusarov I, Shatalin K, Starodubtseva M, Nudler E.
Bacterial nitric oxide synthases (bNOS)
are present in
many Gram-positive species and
have been demonstrated
to synthesize NO from arginine
in vitro and in vivo.
However,
the physiological role of bNOS remains largely unknown.
We show that
NO generated by bNOS
increases the resistance of bacteria to
a broad spectrum of antibiotics,
enabling the bacteria to survive and
share habitats with antibiotic-producing microorganisms.
NO-mediated resistance is achieved through
both the chemical modification of toxic compounds and
the alleviation of the oxidative stress imposed by many antibiotics.
Our results suggest that
the inhibition of NOS activity
may increase
the effectiveness
of antimicrobial therapy.
PMID: 19745150 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/19745150
Bovenstaand artikel werd me toegezonden door Dirk, waarvoor mijn dank.
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