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Stikstofoxide

beschermt bakterien

tegen antibiotika.

 

 

 

 


 

Veel Gram-positieve bacteriŽn zijn in staat om uit arginine stikstofoxide te produceren.

En die stikstofoxide vergroot de resistentie van die bacteriŽn voor antibiotika.

 

En daarmee komen "kwakzalvers" (die antioxidanten, vitamine C, B12 etc. voorschrijven)

opeens in een ander daglicht te staan...

 


 

 

 

Antibiotic resistance clue found

 

 

Page last updated at 00:35 GMT, Sunday, 13 September 2009 01:35 UK

 

 

US scientists have uncovered a defence mechanism in bacteria

that allows them to fend off the threat of antibiotics.

 

...

 

 

http://news.bbc.co.uk/2/hi/health/8248020.stm

 

 


 

Endogenous nitric oxide protects bacteria against a wide spectrum of antibiotics.

Science. 2009 Sep 11;325(5946):1380-4.

Gusarov I, Shatalin K, Starodubtseva M, Nudler E.

 

 

Bacterial nitric oxide synthases (bNOS)

are present in

many Gram-positive species and

have been demonstrated

to synthesize NO from arginine

in vitro and in vivo.

 

However,

the physiological role of bNOS remains largely unknown.

 

We show that

NO generated by bNOS

increases the resistance of bacteria to

a broad spectrum of antibiotics,

enabling the bacteria to survive and

share habitats with antibiotic-producing microorganisms.

 

NO-mediated resistance is achieved through

both the chemical modification of toxic compounds and

the alleviation of the oxidative stress imposed by many antibiotics.

 

Our results suggest that

the inhibition of NOS activity

may increase

the effectiveness

of antimicrobial therapy.

 

PMID: 19745150 [PubMed - in process]

 

 

http://www.ncbi.nlm.nih.gov/pubmed/19745150

 

 


 

Bovenstaand artikel werd me toegezonden door Dirk, waarvoor mijn dank.