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Studie PACE-groep

toont aan:

CGT/GET

is "effectief"

bij 1 op de 7 (!)

chronische vermoeide mensen

 

 

 

 


 

 

 

CGT/GET, het "wondermiddel voor "CVS", leidt, volgens de onderzoekers van PACE zelf,

tot "herstel" bij 22% van mensen met "chronische vermoeidheid"

(mensen met "CVS" volgens de Oxford-criteria of aanpaste Londen-criteria, blz, 188).

 

Aangezien pacing en standaard-medische zorg tot "herstel" leiden bij 8% resp. 7%,

zijn CGT en GET "maar liefst" 14-15% "effectiever" in "CVS"

en dan alleen nog maar in "subjectieve termen" van "vermoeidheid" etc.

 

Zoals eerder door anderen feitelijk onderbouwd, zijn CGT en GET,

zowel in subjectieve als in objectieve termen, ineffectief

zelfs voor patiλnten met "CVS" (klik hier, hier, hier en hier).

 

 


 

Tabellen uit het studierapport die de "herstel"percentages samenvatten:

 

 

Table 1.

Participants, % (n/total), meeting criteria for recovery

 

 

APT

CBT

GET

SMC

Cumulative criteria for trial recovery

 

 

 

 

 

Both CFQ and SF-36-PF

in normal range

16 (25/153)

30 (44/148)

28 (43/154)

15 (22/152)

 

And Oxford criteria not met

15 (23/149)

28 (40/143)

28 (41/144)

14 (21/150)

 

And CGI 1 or 2 (95% CI)

8 (12/149)

22 (32/143)

22 (32/143)

7 (11/150)

 

 

(4–14)

(16–30)

(16–30)

(4–13)

 

Additional criteria for clinical recovery 

 

And International (CDC) CFS criteria not met

8 (12/149)

22 (32/143)

22 (32/143)

7 (11/149)

 

And London ME criteria not met (95% CI)

8 (12/147)

(4–14)

21 (29/139)

(14–29)

21 (29/138)

(15–29)

7 (11/147)

(4–13)

 

 

Table 2.

Composite criteria for trial recovery in subgroups

meeting alternative definitions of CFS or ME at baseline

 

 

 

APT

CBT

GET

SMC

All participants

8 (12/149)

22 (32/143)

22 (32/143)

7 (11/150)

International (CDC) criteria

9 (9/102)

19 (17/89)

22 (20/93)

6 (6/98)

London ME criteria

11 (8/75)

21 (15/70)

21 (16/75)

10 (7/73)

 

 

 


 

 

 

Recovery from chronic fatigue syndrome after treatments given in the PACE trial

Psychological Medicine. 2013. doi:10.1017/S0O3329171300002O.

P. D. White, K. Goldsmith, A. L. ]ohnson, T. Chalder and M. Sharpe;

PACE Trial Management Group

 

 

Background.

 

A multi-centre, four-arm trial (the PACE trial) found that

rehabilitative cognitive behaviour therapy (CBT) and

graded exercise therapy (GET)

were more effective treatments

for chronic fatigue syndrome (CFS)

than specialist medical care (SMC) alone,

when each was added to SMC, and

more effective than

adaptive pacing therapy (APT)

when added to SMC.

 

In this study we compared

how many participants recovered

after each treatment.

 

 

Method.

 

We defined recovery operationally

using multiple criteria, and

compared the proportions of participants

meeting each individual criterion

along with two composite criteria,

defined as

(a) recovery in the context of the trial and

(b) clinical recovery from the current episode of the illness,

however defined, 52 weeks after randomization.

 

We used logistic regression modelling to compare treatments.

 

 

Results.

 

The percentages (number/total) meeting trial criteria for recovery were

22% (32/143) after CBT,

22% (32/143) after GET,

8% (12/149) after APT and

7% (11/ 150) after SMC.

 

Similar proportions met criteria for clinical recovery.

 

The odds ratio (OR) for trial recovery

after CBT was 3.36 [95 % confidence interval (CI) 1.64—6.88] and

for GET 3.38 (95% Cl 1.65—6.93),

when compared to APT,

and after CBT 3.69 (95% CI 1.77—7.69) and

GET 3.71 (95% CI 1.78-7.74),

when compared to SMC (p values <0.001 for all comparisons).

 

There was no significant difference between APT and SMC.

 

Similar proportions recovered

in trial subgroups meeting different definitions of the illness.

 

 

Conclusions.

 

This study confirms that

recovery from CFS is possible, and

that CBT and GET are the therapies most likely to lead to recovery.

 

 

Key words:

 

Chronic fatigue syndrome, cognitive behaviour therapy,

graded exercise therapy, randomized control trial, recovery.

 

 

http://journals.cambridge.org/images/fileUpload/documents/White_PSM_Paper_Jan13.pdf