Volgens een recent literatuuronderzoek zijn de voornaamste neurokognitieve klachten,
t.w. problemen met (het vasthouden van) de aandacht, het geheugen en het reageren,
meetbaar aanwezig, komen de metingen overeen met hetgeen de patiŽnt zelf aangeeft
en hebben die klachten onvermijdelijk invloed op het dagelijkse functioneren.
Citaten uit het uitgebreide studierapport:
In addition to
deficits in information-processing speed,
persons with CFS were impaired on tests
that assess working memory over a sustained period of time
(i.e. N-Back Memory Task, Short Term Memory Scanning Task, Spatial Working Memory).
Immediate recall was impaired, as was delayed recall and recognition.
The deficits in information-processing speed and working memory
identified by this study
may contribute to these problems with initial learning.
Verbal abilities and language were also largely preserved,
except for category fluency,
which may be reliant on working memory for successful completion.
Finally, higher order cognitive functions appear to be intact,
consistent with the findings of previous reviews.
the impairments identified by objective cognitive tests
are congruent with the memory and concentration problems reported by persons with CFS.
The cause of these cognitive deficits is uncertain.
Depression may be a contributing factor
but, as previously discussed,
greater deficits have been found
in people with CFS without co-morbid depression.
this study provides objective evidence of
cognitive deficits in persons with CFS,
primarily in the domains of attention, memory and RT.
Both simple and complex information processing speed are impaired,
along with working memory.
The data also suggest that
memory deficits may be due to the poor initial acquisition of information,
but more studies are needed to investigate this.
The deficits in performance are around 0.5-1.0 S.D. below that of their healthy peers,
which is likely to have an impact on day-to-day activities.
Cognitive functioning in chronic fatigue syndrome: a meta-analysis.
Psychol Med. 2010 Jan 5:1-15. [Epub ahead of print]
Cockshell SJ, Mathias JL.
are commonly reported in
chronic fatigue syndrome (CFS) and
are one of the most disabling symptoms
of this condition.
A number of cognitive deficits
have been identified,
the findings are inconsistent and
hindered by methodological differences.
The current study therefore conducted
a meta-analysis of research
in persons with CFS
the pattern and
magnitude of any deficits
that are associated with this condition.
A comprehensive search of the PubMed and PsycINFO databases for
studies that examined cognitive functioning in CFS
between 1988 and 2008
identified 50 eligible studies.
Weighted Cohen's d effect sizes,
95% confidence intervals and
were calculated for each cognitive score.
in persons with CFS
primarily in the domains of
were not apparent on
fine motor speed,
Persons with CFS demonstrate
moderate to large impairments
in simple and
complex information processing speed and
in tasks requiring working memory over a sustained period of time.
PMID: 20047703 [PubMed - as supplied by publisher]