Pietrangelo:

 

Afwijkende genenexpressie

in de dijbeenspier

verklaart spierklachten

 

 

 

 


 

 

 

Pietrangelo et al hebben de genexpressie in de vastus lateralis (klik hier) onderzocht.

 

En wat blijkt?

 

Afwijkende genenaktiviteit (onder- en overproduktie) bij ME/CVS-patiŽnten betreft m.n.:

  • de stofwisseling/energieproduktie,
  • oxidatieve stress/anti-oxidanten (m.n. super oxide dismutase 2: klik hier),
  • de samenstelling van het spierweefsel (fast twitch/slow twitch: klik hier),
  • spiergroei/-afbraak onder invloed van externe prikkels, bijv. het gebruik, en
  • "aanhechtingsplaatsen"/nicotine acethylcholine receptoren (klik hier) op motorische zenuwcellen, waardoor de zenuwprikkels naar de spieren slechter geleid worden.

Uiteraard trekken de (bio)psychosocialisten zich daar allemaal niets van aan en

bevelen zij zonder scrupules iedereen "evidence-based revalidatietherapieŽn" aan...

 

 


 

Transcription profile analysis of Vastus lateralis muscle from patients with chronic fatigue syndrome.

Int J Immunopathol Pharmacol. 2009 July-September;22(3):795-807.

Pietrangelo T, Mancinelli R, Toniolo L, Toniolo L, Vecchiet J, Fan X00f2 G, Fulle S.

 

 

Chronic fatigue syndrome (CFS) is a disabling condition

characterized byunexplained chronic fatigue that impairs normal activities.

 

Many body systems are affected and

etiology has not yet been identified.

 

In addition to immunological and psychological aspects,

skeletal muscle symptoms are prominent in CFS patients.

 

In an effort to establish

which pathways might be involved in the onset and development of muscle symptoms,

we used global transcriptome analysis

to identify genes

that were differentially expressed in the vastus lateralis muscle

of female and male CFS patients.

 

We found that

the expression of genes

that play key roles in

mitochondrial function and

oxidative balance,

including superoxide dismutase 2,

were altered,

as were genes involved in

energy production,

muscular trophism and

fiber phenotype determination.

 

Importantly,

the expression of a gene encoding

a component of the nicotinic cholinergic receptor binding site was reduced,

suggesting impaired neuromuscular transmission.

 

We argue that

these major biological processes

could be involved in and/or

responsible for the muscle symptoms of CFS.

 

 

PMID: 19822097 [PubMed - as supplied by publisher]

 

 

http://www.ncbi.nlm.nih.gov/pubmed/19822097

 

 


 

Dank aan Brigitte, "korrespondente" uit Vlaanderen.