Gupta Inflammatie 2010

Zowel Brucella als lipopolysacchariden (LPS, endotoxinen: gifstoffen afgescheiden door

gram-negatieve bakteriën) zijn in staat "CVS" (inactiviteit, pijn etc.) te veroorzaken in muizen.

Die "CVS" in muizen gaat gepaard met immuunaktivatie (inflammatie) en oxidatieve stress.

Olijfextrakt lijkt immuunaktivatie/oxidatieve stress en (daarmee?) de klachten te verminderen.

Een slotopmerking voor mensen die het (bio)psychosociale gedachtengoed aanhangen:

Een muis heeft geen gedragsafwijking, "dysfunctionele gedachten"en "bewegingsangst"...

Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive extract.

J Neuroimmunol. 2010 May 25. doi:10.1016/j.jneuroim.2010.05.021.

Gupta A, Vij G, Chopra K.

Abstract

Various putative theories involved in the development of chronic fatigue syndrome

revolve around the role of stress, infection and oxidative stress.

Scientific evidence highlighting the protective role of nutritional supplements

in chronic fatigue syndrome is lacking.

Based on these assumptions,

the present study was designed to evaluate the effect of olive extract

in a mouse model of immunologically-induced fatigue,

wherein purified lipopolysaccharide (LPS) and Brucella abortus (BA) antigen

were used as immunogens.

The assessment of chronic fatigue syndrome

was based on immobility period during chronic water-immersion stress test for 10min daily.

The stress-induced hyperalgesia was measured by tail withdrawal latency.

Mice challenged with LPS or BA for 19days showed

significant increase in the immobility time, hyperalgesia and oxidative stress on the 19th day.

Serum tumor necrosis factor-alpha (TNF-alpha) levels were also markedly increased

with LPS or BA challenge.

Concurrent treatment with olive extract

resulted in a significant decrease in the immobility time as well as hyperalgesia

There was significant attenuation of oxidative stress as well as serum TNF-alpha levels.

The results of the present study strongly indicate

the role of oxidative stress and immunological activation

in the pathophysiology of chronic fatigue syndrome

and highlight the valuable role of olive extract

in combating chronic fatigue syndrome.

Keywords:

Chronic fatigue syndrome, olive extract, immunogen, oxidative stress, tumor necrosis factor-alpha (TNF-α), immobility time, hyperalgesia

PMID: 20537729 [PubMed - as supplied by publisher]