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Overzichtsartikel:

afwijkingen in ME/CVS

die post-exertionele "malaise"

aannemelijk kunnen verklaren

 

 

 

 


 

 

 

In een artikel worden de mogelijke oorzaken van post-exertionele "malaise" in kaart gebracht:

  • energetische afwijkingen en verminderde zuurstofopname worden versterkt door inspanning;
  • spierafwijkingen en de afwijkende fysiologische reactie van spieren op inspanning;
  • landurige oxidatieve en nitrosatieve stress na inspanning;
  • verhoogde pijngevoeligheid en verlaagde pijndrempel bij inspanning;
  • immunologische afwijkingen na een ("kleine") inspanning;
  • cardiologische afwijkingen/verstoorde bloedcirculatie en het gevolg van inspanning;
  • afwijkende reactie van het autonome zenuwstelsel bij inspanning en orthostatische stress; en
  • neurologische afwijkingen in relatie met fysieke en cognitieve stress.

De meeste afwijkingen komen niet voor bij inactieve mensen met of mensen met psychische klachten

en kunnen derhalve niet verklaard worden door "deconditionering" of "psychogene" oorzaken.

 

 


 

 

Deviant cellular and physiological responses to exercise

in Myalgic Encephalomyelitis and chronic fatigue syndrome.

J J Physiology. 2015,1(2): 007.

Twisk FNM, Geraghty KJ.

 

 

Abstract

 

Post-exertional "malaise" is a hallmark symptom of

Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS).

 

Various abnormalities,

including abnormal physiological responses to exertion,

can account for post-exertional "malaise” and "exercise avoidance".

 

Since these abnormalities are not observed in sedentary healthy controls,

the abnormalities and deviant responses cannot be explained by

"exercise avoidance" and subsequent deconditioning, nor by psychogenic factors.

 

 

Keywords:

 

Myalgic Encephalomyelitis; chronic fatigue syndrome; exercise physiology;

energetics; immune system; oxidative and nitrosative stress.

 

 

 

Conclusion

 

Post-exertional "malaise" and "exercise intolerance" are hallmark symptoms [80] of

Myalgic Encephalomyelitis (ME) [1-3] and Chronic Fatigue Syndrome (CFS) [4].

 

This article reviews observations which support the position that

post-exertional "malaise" in ME/CFS may be linked to

a number of observable deviant physiological responses to exercise,

including muscle weakness and myalgia, a substantial fall of oxygen uptake after exercise,

an increase in metabolite-detecting (pain) receptors, increased acidosis,

abnormal immune responses, and orthostatic intolerance.

 

Such findings go some way to explain why many ME/CFS sufferers

either avoid exercise or

report negative effects of exercised-based rehabilitation protocols,

such as graded exercise therapy (GET).

 

The physiological abnormalities induced by ME/CFS

cannot be simply explained by

a sedentary life style and deconditioning [81],

or psychogenic factors [82].

 

While we acknowledge the importance of physical activity in illness rehabilitation,

our findings cast doubt on the efficacy of exercise protocols as a therapeutic approach.

 

More research into exercise-induced cellular and physiological abnormalities

in ME/CFS is needed

to better understanding the illness and its impact on patients, and

to develop appropriate treatments.

 

 

http://www.jacobspublishers.com/images/Physiology/J_J_Physiology_1_2_007.pdf