DAY 1 – THURSDAY, APRIL 7

7:00 - 8:00

REGISTRATION

8:00 – 8:05

WELCOME

James M. Anderson, M.D., Ph.D.,

Division of Program Coordination, Planning and Strategic Initiatives, National Institutes of Health (NIH)

8:05 – 8:15

OPENING REMARKS

Dennis Mangan, Ph.D.,

Office of Research on Women’s Health, NIH

PLENARY OVERVIEW

8:15 – 8:45

Anthony L. Komaroff, M.D.,

Harvard Medical School

The Clinical Presentation of Chronic Fatigue Syndrome

8:45 – 9:15

Leonard A. Jason, Ph.D.,

DePaul University

A Focus on Diagnostic Criteria and Case Definitions

INFECTIOUS DISEASES

NIH Moderator:

Catherine Laughlin, Ph.D.,

National Institute of Allergy and Infectious Diseases, NIH

Co-Moderator:

Harvey J. Alter, M.D.,

Department of Transfusion Medicine, Clinical Center, NIH

9:15 – 9:20

Session Overview

9:20 – 9:40

Ronald Glaser, Ph.D.,

The Ohio State University

Chronic Fatigue Syndrome and the Pathophysiology of EBV Infection: Trying to Connect the Dots to Make Sense

9:40 – 10:00

John Chia, M.D.,

EVMED Research

The Pathogenic Role of Enteroviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

10:00 – 10:15

MORNING BREAK

10:15 – 10:35

Judy A. Mikovits, Ph.D.,

Whittemore Peterson Institute

XMRV and MLV-Related Viruses in Chronic Fatigue Syndrome

10:35 – 10:55

John M. Coffin, Ph.D.,

National Cancer Institute, NIH

Endogenous Retroviral Origin of XMRV and MLV-like Sequences

10:55 – 11:15

Summary and Panel Discussion

SYSTEMS BIOLOGY

NIH Moderator:

Basil Eldadah, M.D., Ph.D.,

National Institute on Aging, NIH

Co-Moderator:

TBN

11:15 – 11:20

Session Overview

11:20 – 11:40

Gordon Broderick, Ph.D.,

University of Alberta

Regulatory Imbalance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Network Biology Perspective

11:40 – 12:00

Mangalathu Rajeevan, Ph.D.,

Centers for Disease Control and Prevention

Genomic Studies of Chronic Fatigue Syndrome

12:00 – 12:20

Keith W. Kelley, Ph.D.,

University of Illinois at Urbana-Champaign

From Systemic Infection to Brain Inflammation

12:20 – 12:35

Summary and Panel Discussion

12:35 – 1:30

LUNCH

IMMUNOLOGY

NIH Moderator:

Timothy A. Gondré-Lewis, Ph.D.,

National Institute of Allergy and Infectious Diseases, NIH

Co-Moderator:

David M. Mosser, Ph.D.,

University of Maryland

1:30 – 1:35

Session Overview

1:35 – 1:55

Mary Ann Fletcher, Ph.D.,

University of Miami, Miller School of Medicine

Immunology of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and GWI

1:55 – 2:15

Benjamin Natelson, M.D.,

Albert Einstein College of Medicine

Chronic Fatigue Syndrome and Fibromyalgia Are Not Always the Same

2:15 – 2:30

Summary and Panel Discussion

2:30 – 2:40

Francis S. Collins, M.D., Ph.D., Director,

National Institutes of Health (NIH)

NEUROLOGY

NIH Moderator:

John Kusiak, Ph.D.,

National Institute of Dental and Craniofacial Research, NIH

Co-Moderator:

Shaheen Lakhan, M.D., Ph.D., M.S., M.Ed.,

Global Neuroscience Initiative Foundation

2:40 – 2:45

Session Overview

2:45 – 3:05

Kathleen C. Light, Ph.D.,

University of Utah

Greater Post-Exercise Gene Expression of Adrenergic and Sensory Receptors and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome versus Multiple Sclerosis, Fibromyalgia, and Healthy Controls

3:05 – 3:20

AFTERNOON BREAK

3:20 – 3:40

Roy Freeman, M.D.,

Beth Israel Deaconess Medical Center, Harvard Medical School

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Autonomic Nervous Systemu

3:40 – 4:00

James Baraniuk, M.D., Georgetown University

Neuroimmunology of Chronic Fatigue Syndrome

4:00 – 4:15

Summary and Panel Discussion

EXEXERCISE PHYSIOLOGY AND ENERGY METABOLISM

NIH Moderator:

Cheryl L. McDonald, M.D.,

National Heart, Lung, and Blood Institute, NIH

Co-Moderator:

Kevin P. Davy, Ph.D.,

Virginia Polytechnic Institute and State University

4:15 – 4:20

Session Overview

4:20 – 4:40

Jane Kent-Braun, Ph.D.,

University of Massachusetts, Amherst

Muscle Function and Fatigue in Chronic Fatigue Syndrome

4:40 – 5:00

Christopher R. Snell, Ph.D.,

University of the Pacific/Pacific Fatigue Lab, Stockton, CA

Cardiopulmonary Exercise Testing and the Assessment of Fatigue in CFS/ME

5:00 – 5:20

Peter C. Rowe, M.D.,

Johns Hopkins University School of Medicine

Orthostatic Intolerance in Chronic Fatigue Syndrome

5:20 – 5:45

Summary and Panel Discussion

DAY 2 – FRIDAY, APRIL 8

7:00 – 8:00

REGISTRATION

8:00 – 8:15

RECONVENE

DIDIAGNOSIS AND BIOMARKERS

NIH Moderator:

Donald G. Blair, Ph.D.,

National Cancer Institute, NIH

Co-Moderator:

Samir Khleif, M.D.,

National Cancer Institute, NIH

8:15 – 8:35

Nancy Klimas, M.D.,

University of Miami, Miller School of Medicine

Immune Based Biomarkers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

8:35 – 8:55

Dane B. Cook, Ph.D.,

University of Wisconsin, Madison

Can Functional Neuroimaging Data Serve as a Biomarker for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?

8:55 – 9:15

Michael Dean, Ph.D.,

National Cancer Institute, NIH

Identifying Genes and Genetic Risk Factors for Complex Diseases

9:15 – 9:35

Summary and Panel Discussion

TREATMENT

NIH Moderator:

Christopher Mullins, Ph.D.,

National Institute of Diabetes and Digestive and Kidney Diseases, NIH

Co-Moderator:

Susan Keay, M.D., Ph.D.,

University of Maryland School of Medicine; and

Veterans Administration Maryland Health Care System

9:35 – 9:40

Session Overview

9:40 – 10:00

Fred Friedberg, Ph.D.,

State University of New York, Stony Brook

Self-Management in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Meaning of "Improvement"

10:00 – 10:20

Italo Biaggioni, M.D.,

Vanderbilt University

Chronic Fatigue and Postural Tachycardia Syndromes

10:20 – 10:35

MORNING BREAK

10:35 – 10:55

Theoharis C. Theoharides, M.D., Ph.D., M.S., F.A.A.A.A.I.,

Tufts University School of Medicine

Substance P-Stimulated TNF Secretion from Human Mast Cells Involves Fission and Translocation of Mitochondria with Extracellular DNA Release That Induces Auto-Inflam­mation, Processes Blocked by the Natural Flavonoid Luteolin

10:55 – 11:15

Lucinda Bateman, M.D.,

Fatigue Consultation Clinic, Salt Lake City

Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome at the Fatigue Consultation Clinic: The Art of Supportive Care Medicine

11:15 – 11:45

Summary and Panel Discussion

11:45 – 1:00

LUNCH

OPPORTUNITIES FOR COMMUNICATION

(A Panel Discussion)

NIH Moderators:

John T. Burklow and Marin P. Allen, Ph.D.,

Office of Communications and Public Liaison, NIH

1:00 – 1:05

Session Overview  

1:05 – 1:15

K. Kimberly McCleary,

CFIDS Association of America

Communicating with Research Stakeholders

1:15 – 1:25

Kenneth J. Friedman, Ph.D.,

Castleton State College

Elephants in the Room: Acknowledging Impediments to Chronic Fatigue Syndrome Research and Education

1:25 – 1:40

Patricia Fero, M.E.P.D.,

Wisconsin ME/CFS Association, Inc.

3 Generations: A View from Wisconsin

Mary M. Schweitzer, Ph.D., MCEAS,

University of Pennsylvania

The Role for Internet in Communication

1:40 – 1:50

John T. Burklow,

Office of Communications and Public Liaison, NIH

1:50 – 2:15

Summary and Panel Discussion

2:15 – 2:30

AFTERNOON BREAK

SUMMARY

NIH Moderator:

Dennis Mangan, Ph.D.,

Office of Research on Women's Health, NIH

Co-Moderator:

Suzanne D. Vernon, Ph.D.,

CFIDS Association of America

2:30 – 4:45

All Speakers and Co-Moderators

Summary of Each Session

Responses by Department of Health and Human Services Federal Agencies

Full Workshop Panel Discussion

4:45 – 5:00

CLOSING COMMENTS

Vivian W. Pinn, M.D.,

Office of Research on Women's Health, NIH