In een overzichtsartikel verschaffen dr. Maes en ondergetekende
een overzicht van de biologische afwijkingen
die een risicofactor voor cardiovasculaire complicaties vormen:
- chronische laaggradige inflammatie (immuunactivatie etc.),
- oxidatieve en nitrosatieve stress (superoxide, stikstofoxide, peroxynitriet),
- uitputting van anti-oxidanten (als gevolgen van oxidatieve/nitrosatieve stress),
- een lekke darm waardoor enterobacteriën in de bloedstroom terecht kunnen komen,
- afname van omega-3- en een toename van omega-6-vetzuren en
- fysiologische stress (o.a. bacteriële/virale infecties) en psychologische stress.
Voor de volledige tekst van onderstaande studie, klik op onderstaand logo:
Chronic fatigue syndrome increases heart disease risk
News - Chronic Fatigue Syndrome News
Written by Matthew Hogg
Saturday, 09 January 2010
A new study sheds light on the underlying mechanisms explaining the increased risk of early death
due to heart failure in chronic fatigue syndrome patients seen in earlier research.
....
http://www.ei-resource.org/news/chronic-fatigue-syndrome-news/chronic-fatigue-syndrome-increases-heart-disease-risk/
Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you:
disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways
may explain cardiovascular disorders in ME/CFS.
Neuro Endocrinol Lett. 2009 Dec 29;30(6). [Epub ahead of print]
Maes M, Twisk FNM.
There is evidence that
disorders in inflammatory and oxidative and nitrosative (IO&NS) pathways and
a lowered antioxidant status
are important pathophysiological mechanisms
underpinning myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
Important precipitating and perpetuating factors for ME/CFS are (amongst others)
bacterial and viral infections;
bacterial translocation due to an increased gut permeability; and
psychological stress.
Recently, Jason et al (2006)
reported that the mean age of
patients with myalgic encephalomyelitis/chronic fatigue syndrome
dying from heart failure, i.e. 58.7 years,
is significantly lower than the age of those dying from heart failure
in the general US population, i.e. 83.1 years.
These findings implicate that
ME/CFS is a risk factor to cardio-vascular disorder.
This review demonstrates that
disorders in various IO&NS pathways
provide explanations for the earlier mortality
due to cardiovascular disorders in ME/CFS.
These pathways are:
- chronic low grade inflammation
with extended production of nuclear factor kappa B and COX-2 and
increased levels of tumour necrosis factor alpha;
- increased O&NS
with increased peroxide levels, and phospholipid oxidation
including oxidative damage to phosphatidylinositol;
- decreased levels of specific antioxidants,
i.e. coenzyme Q10, zinc and dehydroepiandrosterone-sulphate;
- bacterial translocation as a result of leaky gut;
- decreased omega-3 polyunsatutared fatty acids (PUFAs), and
increased omega-6 PUFA and saturated fatty acid levels; and
- the presence of viral and bacterial infections and psychological stressors.
The mechanisms whereby each of these factors
may contribute towards cardio-vascular disorder
in ME/CFS are discussed.
ME/CFS is a multisystemic metabolic-inflammatory disorder.
The aberrations in IO&NS pathways
may increase the risk for cardiovascular disorders.
PMID: 20038921
Samenvatting:
http://www.ncbi.nlm.nih.gov/pubmed/20038921
Volledige artikel:
http://www.rediviva.sav.sk/51i34/106.pdf
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