(met name infekties met M. fermentans, M. homins, M. penetrans en M. arginini
worden door onderzoekers in verband gebracht met longkanker.
Dit zou (mede) bewerkstelligt worden door de aanmaak van BMP2,
waardoor ongekontroleerde groei van tumorcellen in de longen zou kunnen ontstaan.
En de Gezondheidsraad beweerde toch dat het onschuldige mikro-organismen waren?
(klik hier voor meer informatie)
UMDNJ Research Team Discovers that an Infectious Agent May Impact Lung Cancer
UMDNJ Home > About > News/Events > News
Name: Terri Guess
A previously unknown effect of an infectious agent
relevant to the prevention and/or treatment of lung cancer has been discovered
by a UMDNJ research team
led by Melissa Rogers, Ph.D.,
professor of Biochemistry and Molecular Biology at UMDNJ-New Jersey Medical School.
The infectious agent, mycoplasma bacterium,
induces the synthesis of an important growth factor, BMP2, in lung cells.
After enough time, mycoplasma can convert normal lung cells into cells that form tumors.
BMP2 may accelerate this process.
With the help of a two-year grant for $120,000
from the New Jersey Commission on Cancer Research and a Team Science Initiative Grant from UMDNJ,
Dr. Rogers and her collaborator, Dr. John Langenfeld of UMDNJ-Robert Wood Johnson Medical School,
areworking to understand the relationship between bacterial infection and BMP2 in lung tumors.
The relevance of this study stems from the fact that
mycoplasma is a curable bacteria.
"If we think mycoplasma is promoting tumors, especially in lung cancer, then we should be curing it."
"Even though doctors donít normally look at mycoplasma as a pathogen,
it may be a tumor promoter.
"Our linkage of mycoplasma infection to BMP2 induction suggests that
anti-mycoplasma treatment may benefit lung cancer patients," said Rogers.
"Furthermore, understanding how BMP2,
a potent regulator of cell behavior is regulated in normal and
transformed lung cells may identify novel chemotherapy approaches."
Lung cancer is the leading cause of cancer deaths in the country.
Research indicates more people will die from lung cancer than breast, colon, and prostate cancer combined.
Rogers believes this study will lay the groundwork
for examining whether high risk patients should be screened
and treated for mycoplasma infections to prevent lung cancer and
whether lung cancer patients should be treated with antibiotics to eradicate mycoplasma infection.
Mycoplasma infection transforms normal lung cells
and induces bone morphogenetic protein 2 expression by post-transcriptional mechanisms.
J Cell Biochem. 2008 May 15;104(2):580-94.
Jiang S, Zhang S, Langenfeld J, Lo SC, Rogers MB.
Bone morphogenetic protein 2 (BMP2)
is an essential growth factor and morphogen,
whose pattern and level of expression
profoundly influences development and physiology.
We present the novel finding that
mycoplasma infection induces BMP2 RNA production
in six cell lines of diverse types (mesenchymal, epithelial, and myeloid).
Mycoplasma infection triggered
the expression of mature secreted BMP2 protein in BEAS-2B cells
(immortalized human bronchial epithelial cells),
which normally do not express BMP2, and
further increased BMP2 production
in A549 cells (lung adenocarcinoma cells).
mycoplasma is as strong an experimental inducer
as inflammatory cytokines and retinoic acid.
we showed that post-transcriptional mechanisms
including regulation of RNA stability,
rather than transcriptional mechanisms,
contributed to the increased BMP2 expression
in mycoplasma-infected cells.
Furthermore, a novel G-rich oligonucleotide, AS1411
that binds the post-transcriptional regulator nucleolin induced BMP2 exclusively
in infected cells.
Finally, BMP2 stimulated proliferation in BEAS-2B cells
transformed by chronic mycoplasma infection,
as demonstrated by treatment with Noggin, a BMP2 antagonist.
These findings have important implications regarding
the effects of mycoplasma on BMP2-regulated processes,
including cell proliferation, differentiation, and apoptosis.
PMID: 18059017 [PubMed - indexed for MEDLINE]