Volgens een onlangs gepubliceerde studie van het CDC gaat ME/CVS gepaard met
verminderde activering van de basale ganglia,
met name de rechter globus pallidus,
tijdens een gokspelletje met kaarten, waarbij de deelnemer steeds vaker wint.
Die verminderde activiteit van de basale ganglia wordt mogelijk veroorzaakt door immuunactivitatie.
Decreased basal ganglia activation in subjects with chronic fatigue syndrome:
association with symptoms of fatigue.
PLoS ONE. 2014 May 23;9(5): e98156. doi:10.1371/journal.pone.0098156.
Miller AH, Jones JF, Drake DF, Tian H, Unger ER, Pagnoni G.
Reduced basal ganglia function
has been associated with fatigue in neurologic disorders,
as well as in patients exposed to chronic immune stimulation.
Patients with chronic fatigue syndrome (CFS) have been shown to exhibit
symptoms suggestive of decreased basal ganglia function including psychomotor slowing,
which in turn was correlated with fatigue.
CFS patients have been found to exhibit increased markers of immune activation.
In order to directly test the hypothesis of decreased basal ganglia function in CFS,
we used functional magnetic resonance imaging to examine
neural activation in the basal ganglia to a reward-processing (monetary gambling) task
in a community sample of 59 male and female subjects,
including 18 patients diagnosed with CFS according to 1994 CDC criteria and
41 non-fatigued healthy controls.
For each subject,
the average effect of winning vs. losing during the gambling task
in regions of interest (ROI)
corresponding to the caudate nucleus, putamen, and globus pallidus
was extracted for group comparisons and correlational analyses.
Compared to non-fatigued controls,
patients with CFS exhibited significantly decreased activation
in the right caudate (p = 0.01) and right globus pallidus (p = 0.02).
Decreased activation in the right globus pallidus
was significantly correlated with increased
mental fatigue (r2 = 0.49, p = 0.001),
general fatigue (r2 = 0.34, p = 0.01) and
reduced activity (r2 = 0.29, p = 0.02)
as measured by the Multidimensional Fatigue Inventory.
No such relationships were found in control subjects.
These data suggest that
symptoms of fatigue in CFS subjects
were associated with reduced responsivity of the basal ganglia,
possibly involving the disruption of projections
from the globus pallidus to thalamic and cortical networks.