Volgens een recente studie van Kubow,
Sorenson en Jason zijn
de verhoogde concentraties F2- en F3-isoprostanenen isofuranen,
markers voor oxidatieve en nitrosatieve stress,
gecorreleerd aan endocriene afwijkingen (DHEA:cortisol ratio),
in ieder geval in "senioren" met ME/CVS (65 jaar en ouder).
Opmerking FT:
Er zijn diverse plausibele redenen voor HPA-as disfunctie (o.m. bijnier-insufficiëntie) in ME/CVS,
zoals inflammatie, IL-10-productie, en oxidatieve en nitrosatieve stress (artikel in bewerking).
Novel associations of F2-isoprostanes, F3-isoprostanes and isofurans
in older adults with chronic fatigue syndrome: an exploratory study.
Kubow S, Sorenson M, Alkazemi D, Roberts J L II, Adamski KN, Jason LA.
Clin Res. 2015 Jul 15;1(1): doi: 10.16966/clroa.103.
Abstract
Plasma levels of F2-isoprostanes (F2-IsoPs),
a whole body oxidative stress marker,
have been noted to be elevated in populations with chronic fatigue syndrome (CFS).
We hypothesized that the oxidative stress biomarkers of
F2-isoprostanes (F2-IsoPs), isofurans (IsoFs) and F3-isoprostanes (F3-IsoPs)
are related to hypothalamic-pituitary-adrenal (HPA) axis dysregulation
in chronic fatigue syndrome (CFS) subjects
assessed by plasma dehydroepiandrosterone (DHEA) and cortisol and
gene expression of sirtulin-1 [sirtuin-1, FT] (SIRT1).
Plasma samples were obtained from nine CFS individuals aged 65 years or older.
The mean levels of plasma F2-IsoPs (M=178 pg/ml, SD=100) and IsoFs (M=266 pg/ml, SD=205)
were several-fold higher than previously reported in healthy subjects.
F2-IsoPs:F3-IsoPs and SIRT1 were negatively associated (r=– .674, p<.05)
whereas F3-IsoPs were inversely correlated with DHEA (r=– .586, p<.05) and
positively associated with SIRT1 (r=.733, p<.05).
After correction for age and sex,
the F2-IsoPs:IsoFs ratio was positively correlated to DHEA:cortisol (r=.758, p<.05).
The findings indicate
that plasma IsoFs and F2-IsoPs are elevated in older subjects with CFS and
that isoprostane and isofuran ratios are associated with HPA dysregulation.
Keywords:
Chronic fatigue syndrome; isoprostanes; isofurans; cortisol;
hypothalamic-pituitary-adrenal axis; mass spectrometry
Bron:
https://www.sciforschenonline.org/journals/clinical-research/article-data/
CLROA-1-103/CLROA-1-103.pdf
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