Oxidative stress levels are raised in chronic fatigue syndrome
and are associated with clinical symptoms
Free Radical Biology & Medicine 2005; 39(5): 584-9
G Kennedy, VA Spence, M McLaren, A Hill, C Underwood, JJF Belch
The aetiology of chronic fatigue syndrome (CFS) is unknown; however, recent
evidence suggests that excessive free radical (FR) generation may be
involved. This study investigated for the first time levels of
8-iso-prostaglandin-F2a-isoprostanes alongside other plasma markers of
oxidative stress in CFS patients and control subjects.
Forty-seven patients (18 males, 29 females, mean age 48 [19–63] years) who
fulfilled the Centres for Disease Control classification for CFS and 34
healthy volunteers (13 males, 21 females, 46 [19–63] years) were enrolled
in the study. The CFS patients were divided into two groups; one group had
previously defined cardiovascular (CV) risk factors of obesity and
hypertension (group 1) and the second were normotensive and nonobese (group 2).
Patients had significantly increased levels of isoprostanes (group 1, P = 0.007;
group 2, P = 0.03, unpaired t test compared to controls) and oxidised
low-density lipoproteins (group 2, P = 0.02) indicative of a FR attack on
lipids. CFS patients also had significantly lower high-density
lipoproteins (group 1, P = 0.011; group 2, P = 0.005). CFS symptoms
correlated with isoprostane levels, but only in group 2 low CV risk CFS
patients (isoprostanes correlated with; total symptom score P = 0.005;
joint pain P = 0.002; postexertional malaise P = 0.027, Pearson).
This is the first time that raised levels of the gold standard measure of in vivo
oxidative stress (isoprostanes) and their association with CFS symptoms have been reported.
- Geaksepteerde oxidatieve stress-markers (zoals isoprostane) zijn aantoonbaar verhoogd.
- Er is een sterke relatie tussen deze "vrije radikalen-marker" en de ernst van de klachten.