Pheby en Saffron hebben een onderzoek uitgevoerd onder een grote groep patiënten.
De belangrijkste konklusies (zie ook onderstaande citaten):
- Persoonlijkheidskenmerken spelen geen rol als het gaat om de ernst van de ziekte.
- Vroege diagnose/snel ingrijpen
voorkomt dat patiënten de meest ernstige vorm van ME "ontwikkelen".
- De sterke associatie tussen een moeder met CVS en een kind met ME/CVS
(die er niet met de vader is) wijst op een erfelijke komponent (mitochondria?)
en weerspreekt de bewering van "vermoeidheidsdeskundigen" uit Utrecht
(klik hier)
dat vaders een psychologische invloed uitoefenen!
Enkelijke citaten uit het uitgebreide studierapport:
Early management of the illness
appeared
the most important determinant of severity.
Personality type did not appear to constitute a risk factor for severe disease.
Our investigation of the possible role of personality revealed
an inverse association between neuroticism and severity,
but none overall between conscientiousness and severity.
In the conscientiousness domain,
though there was no association overall with severity,
the sub-domains of self-efficacy and self-discipline were associated with it.
The strong association with having a mother with ME/CFS,
but lack of association with having a father with the condition,
is consistent with
ME/CFS being associated with disturbed mitochondrial function.
Mitochondrial DNA is of course entirely of maternal origin.
Risk factors for severe ME/CFS
Biology and Medicine, Vol 1 (4): 50-74, 2009 50-74
Derek Pheby, Lisa Saffron.
ME/CFS is a serious illness affecting several hundred thousand British people.
Some 25% of people with ME/CFS may be severely ill (housebound or bedbound), sometimes for decades.
This observational, questionnaire-based study
was designed to identify risk factors for severe disease.
Exposure to potential risk factors,
including familial risks, personality, and early management of the illness,
was compared in 124 people with severe disease and 619 mildly ill controls.
Severity
was determined by self-report and the Barthel (activities of daily living) Index.
Premorbid personality
was assessed using
the Neuroticism and Conscientiousness domains of
the IPIP scale.
Analysis was by tests of association and logistic regression.
Early management of the illness appeared
the most important determinant of severity.
Having a mother with ME/CFS was also important.
Smoking and personality were not risk factors,
neurotic traits being more frequent among the less severely ill.
Conscientiousness overall was not related to severity.
Keywords:
Chronic fatigue syndrome, myalgic encephalomyelitis, epidemiology, prognosis, severity, risk factors, treatment, management.
full-text:
http://www.biolmedonline.com/Articles/vol1_4_50-74.pdf
Met dank aan Rob en Dean.
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