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Weinstein:

 

Vermoeidheid/vermoeidbaarheid

worden niet weerspiegeld in

objektieve metingen van de inspanningskapaciteit.

 

 

 

 


 

De inspanningskapaciteit van ME/CVS-patiŽnten, gemeten m.b.v. een zogenaamde fietstest,

is, volgens een recente studie van Wienstein en kollega's, beduidend minder.

 

De mate waarin iemand aangeeft vermoeid te zijn/vermoeid te raken (subjektief!)

heeft echter geen duidelijke relatie met de harde cijfers uit de inspanningstest.

 

Het aktiviteitennivo is wel duidelijk gerelateerd aan de uitkomsten van de fietstest.

 

De uitkomsten van deze studie, alhoewel klein, heeft belangrijke implikaties:

  1. De mate van invaliditeit kan "geobjektiveerd" worden (m.b.v. een fietstest)
  2. De inspanningskapaciteit van ME/CVS-patiŽnten is aanzienlijk gereduceerd.
  3. Subjektieve diagnosekriteria hebben zeer weinig waarde:
  4. het "vermoeidheidskriterium" voor "CVS" selekteert "chronisch vermoeide mensen".

 


 

Exploratory analysis of the relationships between

aerobic capacity and self-reported fatigue

in patients with rheumatoid arthritis, polymyositis, and chronic fatigue syndrome.

PM R. 2009 Jul;1(7):620-8.

Weinstein AA, Drinkard BM, Diao G, Furst G, Dale JK, Straus SE, Gerber LH.

 

 

OBJECTIVE:

 

To determine

if self-reported levels of physical activity and fatigue

are related to peak oxygen uptake (VO(2peak)) and

whether these relationships differ among the patient groups

(rheumatoid arthritis [RA], polymyositis [PM], and chronic fatigue syndrome [CFS]).

 

 

DESIGN:

 

Correlational investigation.

 

 

SETTING:

 

Two ambulatory research clinics

at the National Institutes of Health, Clinical Center, Bethesda, MD.

 

 

PARTICIPANTS:

 

There were 9 patients with PM, 10 with RA, and 10 with CFS.

 

All patients met case criteria for their respective diagnoses.

 

 

METHODS/MAIN OUTCOME MEASUREMENTS:

 

VO(2peak) during bicycle ergometry and

self-reported fatigability, fatigue, and physical activity.

VO(2peak) was used as the criterion measurement of physiological fatigue

with which the self-reported variables were compared.

 

 

RESULTS:

 

The Pearson r revealed that

self-reported physical activity correlated with VO(2peak)

(r = 61, P = .01).

 

However,

fatigability and fatigue did not correlate with VO(2peak).

 

Linear regression analysis was performed

to assess the effects of diagnosis group,

self-reported activity level or fatigue, and their interaction.

 

A trend in the data showed a

distinctive relationship between fatigue/fatigability within the 3 groups.

 

In addition, when controlling for group status,

self-reported activity predicted aerobic capacity as measured by VO(2peak).

 

 

CONCLUSIONS:

 

This study confirms that patients with chronic, but stable RA, PM, or CFS

are fatigued and have significantly decreased aerobic capacity.

 

Self-reports of physical activity predicted VO(2peak), and

may be used as an indicator of activity-based aerobic capacity.

 

Self-reports of fatigue, however, did not correlate with VO(2peak) and

hence are assessing something other than an index of aerobic capacity, and

provide additional information about patients' perceptions,

which will require further investigation.

 

 

PMID: 19627955 [PubMed - in process]

 

 

 

http://www.ncbi.nlm.nih.gov/pubmed/19627955

http://www.pmrjournal.org/article/S1934-1482(09)00436-5/abstract#cor1