Follow FrankTwisk on Twitter  





Simon hits again:


XMRV niet gevonden bij 186 patiŽnten!






Zoals te verwachten was van een studie door "vermoeidheidsdeskundigen" .....






Invest in ME Suzanne Vernon (CAA)



Berichtgeving in de media:









Research finds o proof that a virus is the cause of ME


By Michelle Roberts

Health reporter, BBC News




Professor Myra McClure ... said: "We are confident that our results show

there is no link between XMRV and chronic fatigue syndrome, at least in the UK."




"If it had been there, we would have found it."






Failure to detect the novel retrovirus XMRV in chronic fatigue syndrome

PLoS ONE 2010;5(1): e8519. doi:10.1371/journal.pone.0008519.

Erlwein O, Kaye S, McClure MO, Weber J, Wills G, Collier D, Wessely S, Cleare A.






In October 2009 it was reported that

68 of 101 patients with chronic fatigue syndrome (CFS) in the US

were infected with a novel gamma retrovirus,

xenotropic murine leukaemia virus-related virus (XMRV),

a virus previously linked to prostate cancer.


This finding, if confirmed, would have a profound effect on the understanding and treatment of an incapacitating disease affecting millions worldwide.


We have investigated CFS sufferers in the UK to determine if they are carriers of XMRV.





Patients in our CFS cohort had undergone medical screening

to exclude detectable organic illness and

met the CDC criteria for CFS.


DNA extracted from blood samples of 186 CFS patients were screened

for XMRV provirus and

for the closely related murine leukaemia virus

by nested PCR using specific oligonucleotide primers.


To control for the integrity of the DNA,

the cellular beta-globin gene was amplified.


Negative controls (water) and

a positive control (XMRV infectious molecular clone DNA)

were included.


While the beta-globin gene was amplified in all 186 samples,

neither XMRV nor MLV sequences were detected.





XMRV or MLV sequences were not amplified from DNA originating from CFS patients in the UK.


Although we found no evidence that XMRV is associated with CFS in the UK,

this may be a result of

population differences between North America and Europe

regarding the general prevalence of XMRV infection, and

might also explain the fact that two US groups found XMRV in prostate cancer tissue,

while two European studies did not.




Received: December 1, 2009;

Accepted: December 4, 2009;

Published: January 6, 2010









Met dank aan Brigitte.