In een open brief aan McClure (mede-auteur van de Wessely XMRV-studie, woordvoerder)
maakt Annette Whittemore van het Whittemore-Peterson Instituut een aantal zaken glashelder:
- De patiŽnten uit de Mikovits-studie waren afkomstig uit alle delen van de VS,
en dus niet, zoals vermoeidheidsdeskundigen telkens beweren, van de Lake Tahoe-epidemie.
- Dr. Kerr, dr. Gow en kollega's en onze vermoeidheidsdeskundigen wisten,
vůůrdat zij hun resultaten naar buiten brachten,
dat de onderzoekers van het Whittemore-Peterson Instituut
met de originele laboratoriumtechniek (beschreven in Lombardi-Mikovits-studie)
wťl XMRV-infekties bij de betrokken patiŽnten vastgesteld hadden.
Annette Whittemore biedt in de brief tevens aan om:
- het onderzoekteam van McClure positieve bloedstalen en reaktanten op te sturen,
zodat zij kunnen aantonen dat ze, met de door hen gebruikte laboratoriummethodiek,
in staat zijn om XMRV-infekties op te sporen.
- bloedmonsters van de onderzoeksgroep van McClure en andere teams te onderzoeken
met de laboratoriumtechniek van het Whittemore-Peterson Instituut (Mikovits-studie).
Het zal mij benieuwen wie de handschoen durft op te pakken...
WPI Letter to Dr. McClure
April 12, 2010
Dear Dr. McClure:
On behalf of the Whittemore Peterson Institute in Reno, Nevada (WPI),
I am writing you today to ensure that there is direct communication between WPI and your research team.
You may share this letter with others that you deem appropriate,
and I will do the same by sharing this letter with other interested parties in both the United States and the United Kingdom.
On January 6, 2010, you reported in PloS One that
you failed to detect xenotropic murine leukemia virus-related virus (XMRV) in ME/CFS patient samples.
In that publication you reported the following conclusion,
[b]ased on our molecular data,
we do not share the conviction that XMRV may be a contributory factor in the pathogenesis of ME/CFS, at least in the U.K.
You subsequently made the following statement in your commentary
regarding the Netherlands study in the BMJ, ... van Kuppeveld and colleagues provide the additional information reported at a conference last year that
the patients in question came
from an outbreak of chronic fatigue syndrome at Incline Village on the northern border of Lake Tahoe in the mid-1980s.
This statement about the origin of the 101 patient samples is untrue.
The patients in the Science study were well defined in the paper as having CFS by the Fukuda and Canadian consensus definitions of ME/CFS.
More importantly the patient samples did not come from the Lake Tahoe outbreak as you assert,
but rather from patients
who had become ill while living in various parts of the United States.
We would also like to report that
WPI researchers have previously
detected XMRV in patient samples from both Dr. Kerr's and Dr. van Kuppeveld's cohorts
prior to the completion of their own studies, as they requested.
We have email communication that confirms both doctors were aware of these findings before publishing their negative papers.
In addition, Dr. van Kuppeveld asked for and received reagents and a positive patient sample
to determine if his testing procedures could in fact detect XMRV in a positive blood sample before he published his paper.
We wonder why these materials were not used in his study which also failed to detect XMRV.
One might begin to suspect that the discrepancy between our findings of XMRV
in our patient population and patients outside of the United States, from several separate laboratories,
are in part due to technical aspects of the testing procedures.
To help identify the possible reasons for the discrepancies in detection of XMRV,
WPI would like to send you known positive patient samples with controls,
from the United States in an appropriate number, along with WPI reagents,
so that we can help you determine whether
your testing methodologies will accurately detect XMRV in a clinical sample of blood.
In addition, WPI would be willing to test a like number of samples from your patient cohort
to see if our researchers can detect XMRV in those samples.
This critical exercise would help resolve the question of whether
you are using all of the appropriate techniques necessary to detect XMRV in a patients ample.
If your tests are able to detect XMRV correctly in the known positives,
then the debate can appropriately center on whether we can identify
the differences in the patient cohorts which have been the subject of various studies.
It is in this systematic manner that we all may help to move the science forward; instead of continuing
to debate whether or not ME/CFS patients in Europe are infected with XMRV.
It is also important to note that our initial study was not intended to prove causality of ME/CFS,
but to report a significant association between patients who had been diagnosed with ME/CFS and XMRV.
We believe that there exists compelling evidence to spur additional scientific review,
especially in light of the fact that our team of researchers also discovered XMRV in the blood of 3.7% of our non contact controls.
I look forward to your timely reply.
Founder and CEO Whittemore Peterson Institute
Met dank aan Rubia