A third pathogenic and lymphotropic human retrovirus
AIDS Rev. 2010; 12: 121-122.
Johan van Weyenbergh.
Chronic fatigue syndrome
is characterized by
persistent or relapsing debilitating fatigue,
musculoskeletal pain, and
as well as immunological abnormalities
(Reeves, et al. BMC Med. 2005;3:19; Devanur, et al. Clin Virol. 2006;37:139-50).
If the retroviral link revealed by Lombardi, et al. turns out to be "druggable",
CFS will automatically upgrade
from a neglected disease to a "hot target" for the pharmaceutical industry.
the sequence data presented by Lombardi, et al., albeit limited,
seems to suggest that XMRV, much like HTLV 1
(Van Dooren, et al. Mol Biol Evol. 2004;21:603 11),
may be a slowly evolving retrovirus,
indicating viral propagation might occur mainly through host cell replication
rather than through HIV-like, reverse transcriptase-mediated, cell-to-cell spread.
previously described outbreaks of "epidemic" CFS,
e.g. in a symphonic orchestra, a school, and a convent,
challenge an HIV like epidemiological spread.
CD4 or CD8 T -cell subsets are not quantitatively different in CFS patients
(Tirelli, et al. Scand J Immunol. 1994;40:601-8),
but altered NK cell levels and function have been repeatedly reported.
considering the pathogenic profile, molecular evolution, and broad cellular tropism,
XMRV seems to display HTLV-1-like characteristics.
much unlike HIV-1/AIDS and HTLV-1-associated illnesses,
adult T -cell leukemia/lymphoma (ATLL) and
HTLV 1-associated myelopathy/tropic spastic paraparesis (HAM[TSP),
where disease onset takes years or decades, respectively,
CFS is generally characterized by a sudden onset,
most often accompanied by
Met dank aan Rob, die me attendeerde op bovenstaand artikel.