A third pathogenic and lymphotropic human retrovirus
AIDS Rev. 2010; 12: 121-122.
Johan van Weyenbergh.
....
Chronic fatigue syndrome
is characterized by
persistent or relapsing debilitating fatigue,
musculoskeletal pain, and
neurocognitive difficulties,
as well as immunological abnormalities
(Reeves, et al. BMC Med. 2005;3:19; Devanur, et al. Clin Virol. 2006;37:139-50).
....
If the retroviral link revealed by Lombardi, et al. turns out to be "druggable",
CFS will automatically upgrade
from a neglected disease to a "hot target" for the pharmaceutical industry.
....
First,
the sequence data presented by Lombardi, et al., albeit limited,
seems to suggest that XMRV, much like HTLV 1
(Van Dooren, et al. Mol Biol Evol. 2004;21:603 11),
may be a slowly evolving retrovirus,
indicating viral propagation might occur mainly through host cell replication
rather than through HIV-like, reverse transcriptase-mediated, cell-to-cell spread.
....
However,
previously described outbreaks of "epidemic" CFS,
e.g. in a symphonic orchestra, a school, and a convent,
challenge an HIV like epidemiological spread.
....
Likewise,
CD4 or CD8 T -cell subsets are not quantitatively different in CFS patients
(Tirelli, et al. Scand J Immunol. 1994;40:601-8),
but altered NK cell levels and function have been repeatedly reported.
Thus,
considering the pathogenic profile, molecular evolution, and broad cellular tropism,
including pan-lymphotropism,
XMRV seems to display HTLV-1-like characteristics.
....
However,
much unlike HIV-1/AIDS and HTLV-1-associated illnesses,
adult T -cell leukemia/lymphoma (ATLL) and
HTLV 1-associated myelopathy/tropic spastic paraparesis (HAM[TSP),
where disease onset takes years or decades, respectively,
CFS is generally characterized by a sudden onset,
most often accompanied by
flu-like syndromes.
http://www.aidsreviews.com/files/2010_12_2_121-123.pdf
Met dank aan Rob, die me attendeerde op bovenstaand artikel.
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